Journal article
Drusen and Other Retinal Findings in People With IgA Glomerulonephritis
U Greferath, E Fletcher, J Savige, HG Mack
American Journal of Ophthalmology | ELSEVIER SCIENCE INC | Published : 2024
Abstract
Purpose: Retinal drusen have been described in people with IgA nephropathy. We examined the frequency of drusen in IgA nephropathy and compared their location and composition with those for drusen in age-related macular degeneration. Design: Immunohistological case series of eyes of patients with IgA nephropathy, and a comparison eye with age-related macular degeneration. Methods: Donor eyes from 4 individuals (3 male, 1 female, aged 40-80 years) with biopsy-proven IgA nephropathy and kidney failure were examined for the presence of drusen, and location and composition using antibodies for vitronectin, IgA, IgM, IgG, C3, and C1q. Results were compared with those for drusen in macular degener..
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Grants
Awarded by Royal Melbourne Hospital
Funding Acknowledgements
This study was supported by funding from the NHMRC to Erica Fletcher (no. APP1181010) . Heather G. Mack has received honoraria from Novartis. The other authors indicate no financial support or conflicts of interest. All authors attest that they meet the current ICMJE criteria for authorship. Author Contributions: Conceptualization: J.A.S., H.G.M.; Investigation: U.G.; Data curation: H.G.M.; Visualization: U.G.; Resources: EF, JAS; Writing - original draft: H.G.M.; Writing - review and editing: U.G., E.F., J.A.S., H.G.M. Acknowledgments: The authors are grateful to the Australian Ocular Biobank, New South Wales Organ and Tissue Donation Service, Sydney, New South Wales, Australia, and the donors and families, who made this research possible. IgA, IgM, IgG, C1q, and C3 antibodies were generously supplied as a gift by Ahida Batrouney, The Royal Melbourne Hospital, Victoria, Australia.